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Istradefylline forty mg/day enhanced peak degrees and AUC of CYP3A4 substrates in scientific trials. This effect wasn't noticed with istradefylline twenty mg/day. Take into account dose reduction of delicate CYP3A4 substrates.fosphenytoin will lower the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Ca